Mitochondrial morphology and cellular distribution are altered in SPG31 patients and are linked to DRP1 hyperphosphorylation, Lavie et al, Hum Mol Genet

Mitochondrial morphology and cellular distribution are altered in SPG31 patients and are linked to DRP1 hyperphosphorylation

By Lavie J, Serrat R, Bellance N, Courtand G, Dupuy JW, Tesson C, Coupry I, Brice A, Lacombe D, Durr A, Stevanin G, Darios F, Rossignol R, Goizet C, Bénard G.

Hum Mol Genet (advance online Dec 22, 2016)

 

Figure: Mitochondrial fission is altered in SPG31 fibroblasts.

Mitochondrial fusion assay with control and patient fibroblasts. Cells were stained with MitoTracker reagent and mitochondrial shapes were analyzed by live-imaging before FCCP treatment (10 μM), 10 min after FCCP treatment, and then 0, 30, 60, and 90 min after FCCP washout, as indicated

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